Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TCDD-35 | TC35_2003 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+NFV | 65 |
| 2 | 3TC+AZT+IDV | 18 |
| 3 | 3TC+AZT+NFV | 60 |
| 4 | D4T+DDI+NVP | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, Q151M, M184V, T215FY | K219E | Y181C, G190A | T27S, V35T, E36A, T39E, E53D, V60I, K122E, D123S, S162Y, K166R, K173A, Q174K, D177E, I178L, T200A, E203EK, Q207E, R211K, K223KE, L228H, V245Q | R172I |
| >TC35_2003| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTAICEELEKEGKISKIGPDNPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQYSMTRILEPFIAKNPELVI CQYVDDLYVASDLEIGQHRAKIKELREHLLKWGFYTPDEKHQEEPPFHWMGYELHPDKWT VQPIQLPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, K20I, M36I, R41K, D60E, Q61E, L63P, H69K, I93L |
| >TC35_2003| codons 1-99 PQITLWQRPLVSIKVGGQIIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE EIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |