Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TC12 | TC12_2003 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 135 |
| 2 | 3TC+DDI | 39 |
| 3 | Unknown | 35 |
| 4 | APV+EFV+IDV | 26 |
| 5 | 3TC+D4T+NVP | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, R41K, L63LI, H69K, I72IV, L89M, I93L |
| >TC12_2003| codons 8-99 RPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIIIEIC GKKAVGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V | K103N | V35R, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, I178L, I195L, G196V, T200A, Q207E, R211K, L228I, V245Q |
| >TC12_2003| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALRAICEELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPELVI YQYVDDLYVGSDLELVQHRAKIEELREHLLKWGFTTPDKKHQKEPPFIWMGYELHPDKWT VQPIQLPEKDSWT |
References
| Author | Title | Citation |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |