Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TC-41 | TC41_2003 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 104 |
| 2 | 3TC+AZT+NVP | 43 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | A62AV, K219KQ | Y181YC | V35T, T39E, K103R, K122E, D123S, I142T, K173T, Q174K, T200A, Q207E, R211K, F214L |
| >TC41_2003| codons 1-232 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPV FVIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI CQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDQKHQKEPPFLWMGY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| W6WG, T12TP, I15V, L19LI, E35D, M36I, R41K, K45R, R57K, L63PS, H69K, L89M, I93L |
| >TC41_2003| codons 1-99 PQITLGQRPLVPIKVGGQIKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVKQYD QISIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |