Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5232 | CA12873 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+RTV+SQV | 4 |
| 2 | 3TC+AZT | 8 |
| 3 | 3TC+AZT+IDV | 21 |
| 4 | 3TC+AZT+SQV | 17 |
| 5 | 3TC+AZT+IDV | 47 |
| 6 | 3TC+AZT+IDV+SQV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37D, K45KR, I62V, L63P, A71T, I72V, I93L |
| >CA12873| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPRMIGGIGGFIKVRQYD QVPIEICGHKTVGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, T215FS | K20KR, R83K, K122E, D123N, Q174R, T200I, Q207E, R211K, A272P, Q278X, I293V, E297A |
| >CA12821| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGTKALTEVVPLTAEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |