<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+AZT+NFV+NVP 13
2 None 69
3 3TC+ABC+AZT+NFV+NVP 9
4 None 91
5 3TC+AZT+LPV 48
6 3TC+ATV+DDI+RTV+TDF 61
7 DDI+APV+RTV+TDF 61
8 None 57
9 3TC+ABC+ATV+DDC+RTV+TDF 19
10 DDI+RAL+TDF+3TC+ABC 21

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
N155H G163K E11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KR  
>CA128619| codons 9-288
QEDHEKYHSNWRAMANDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHL
EGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTVHTDNGPNFISNAVKA
ACWWAGIKQEFGIPYNPQSQGVVESMHKELKKIIKQVRDQAEHLKTAVQMAVFIHNFKRK
GGIGGYSAGERIIDIIATDIQTRELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGA
VVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    K20R, E35D, M36I, N37NK, I62V, L63P, I64L, I72V  
>CA123335| codons 1-99
PQITLWQRPLVTIKIGGQLREALLDTGADDTVLEDIKLPGRWKPKMIGGIGGFIKVRQYD
QVPLEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N   K20R, V35I, K122E, I178IM, T200A, E203EK, R211K, V245Q, A288AT, V292VI, I293V, E297A  
>CA123336| codons 1-299
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYMDDLYVGSDLEIGQHRAKIKELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKTLTEIVPLTAEA

References
Author Title Citation
Blanco, JL HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis, 2011