Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5242 | CA12837 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | None | 104 |
| 3 | IDV+ D4T+ 3TC | 104 |
| 4 | None | 20 |
| 5 | DDI+ D4T+ NFV | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184MV | N348I | V179D | V118I, K122E, I135T, I142IV, T200A, F214L, K277R, I293V, I326T, R356K, T386I, K431KR, E432ED, R463RK, V466VA, T477TA, Q480QH, E492A, K527N, A554S, I556IV, K558KR | A299AG |
| >CA12837| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEGE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLERDPIVGAETFYVDGAANRETKLGKAGYVTDRGKQKAVSLTDTTNQKAELH AIHLALQDSGLAVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLINKEKVYLAWVPAHK GIGGNEQVDKLVSSGVRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, V82A | I62V, L63P, I64V |
| >CA12880| codons 14-99 KIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYDQVPVEICGHKAIG TVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |