Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5217 | CA12804 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 108 |
| 2 | AZT+ 3TC | 100 |
| 3 | D4T+ DDI+ NFV | 110 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | T4D, K20KM, L63P, H69Q, T74S, V77I, I93L |
| >CA12804| codons 1-99 PQIDLWQRPLVTIKIGGQLMEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKAIGSVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K43KN, K104R, I142V, T200A, Q207E, R211K, L228H, T286A, I293IV, E297EK, K311KR, M357MIT, K366KR, T369TA, A376AT, T377TIM, K390KR, A400T, T403TA, E404ED, V435IT, A437AV, D460N, R461RK, V467I, H483HY, L491LS, A554ADNT, V559VI |
| >CA12524| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLAEAVQKITMESIVIWGKTPKFRLPIQKETWETWWADYWQATWIPEWEFVNTP PLVKLWYQLEKEPITGVETFYVDGAANRETKLGKAGYVTNKGRQKVISLTDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKIL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |