Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5212 | CA12797 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 239 |
| 2 | 3TC+AZT | 109 |
| 3 | 3TC+AZT+IDV | 22 |
| 4 | 3TC+D4T+IDV | 35 |
| 5 | 3TC+D4T+NFV | 106 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10F, N88ND | K20KI, D60E, Q61E, I62V, L63P, V77VI, I93L, C95CS |
| >CA12797| codons 7-99 QRPFVTIKIGGQLIEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYEEVPIEI CGHKAIGTVLIGPTPVNIIGRDLLTQLGSTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T69D, K70R, M184V, T215FS | K219Q | A98AG | K20R, T39AE, V60I, K102X, V118I, D123E, S134SR, I135T, I142L, K166R, I178IM, I202V, R211RK, F214L, L228H, A272P | N136NS, E138EV |
| >CA12519| codons 1-276 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKXKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPRTSNVTPGLRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKV |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |