Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI+RTI | NA |
| 2 | RAL | 22 |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| G140S, Q148H | G163R | S17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208L |
| >H-SH2-W22| codons 1-288 FLDGIDKAQEEHEKYHNNWKAMASDFNIPPVVAKEIVACCDKCQLKGEAMHGQVDCSPGI WQLDCTHLERKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSAAVKAACWWAGIKQEFSIPYNPQSHGVVESMNKELKKIIRQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDLQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Malet, I | Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. | AAC, 2008 |