Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5147 | CA12725 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | DDC | 114 |
| 3 | AZT+ DDC+ 3TC | 50 |
| 4 | IDV+ AZT+ 3TC | 134 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L24I | L19V, I64V, I72M |
| >CA12725| codons 1-99 PQITLWQRPLVTIKIGGQVKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QILVEICGHKAMGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219R | K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203K, R211K, K223Q, L228R, A272P, T286A |
| >CA12440| codons 1-297 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELESDGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKENPDIVI YQYVDDLYVGSDLEIGLHRTKIKELRQHLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |