Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1549 | CA12713 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 187 |
| 2 | 3TC+AZT | 67 |
| 3 | 3TC+D4T+IDV | 39 |
| 4 | DDC+DLV+NFV+SQV | 22 |
| 5 | 3TC+D4T+NFV+SQV | 63 |
| 6 | APV+D4T+EFV | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33I, K43T, G73S | L10I, I15V, K20R, M36I, Q61N, L63P, A71V |
| >CA12713| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVIEEINLPGRWTPKLIGGIGGFVKVRQYD NIPIEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | K103N | K43E, E44A, A98S, V111I, V118I, I135T, I142V, E203K, H208Y, R211K, F214L, K223Q, L228R, I257L, A272P, I274IV, K277R, T286A, I293V | I270IL |
| >CA12427| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGLYTPDRKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQLYPGVKVRQLCKLLRGAKALTEVVPLTEEAE LE |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |