<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5092 CA12655 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 Unknown 52
2 3TC+AZT+IDV 6

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54IV, L76V   L10V, I13V, I15V, K20T, N37D, K43R, R57K, I62V, L63P, I66F, A71V, I72IK  
>CA12655| codons 1-99
PQITLWQRPVVTVKVGGQLTEALLDTGADDTVLEEMDLPGRWRPKIIGGIGGFVKVKQYD
QVPIEFCGHKVKGTVVVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F K219Q     E6D, K20R, T27S, V35I, V60I, T69N, R83K, K101R, I135T, N175Y, T200E, E203D, L228LP, T240TS D218DV
>CA12374| codons 1-251
PISPIDTVPVKLKPGMDGPRVKQWPLSEEKIKALIEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPDIVI
YQYVDDLYVGSDLEIGQHREKIDELRQHLLRWGFFTPVQKHQKEPPFPWMGYELHPDKWS
VQPIVLPEKDS

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005