Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5092 | CA12655 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+AZT+IDV | 6 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, L76V | L10V, I13V, I15V, K20T, N37D, K43R, R57K, I62V, L63P, I66F, A71V, I72IK |
| >CA12655| codons 1-99 PQITLWQRPVVTVKVGGQLTEALLDTGADDTVLEEMDLPGRWRPKIIGGIGGFVKVKQYD QVPIEFCGHKVKGTVVVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | E6D, K20R, T27S, V35I, V60I, T69N, R83K, K101R, I135T, N175Y, T200E, E203D, L228LP, T240TS | D218DV |
| >CA12374| codons 1-251 PISPIDTVPVKLKPGMDGPRVKQWPLSEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPDIVI YQYVDDLYVGSDLEIGQHREKIDELRQHLLRWGFFTPVQKHQKEPPFPWMGYELHPDKWS VQPIVLPEKDS |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |