Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14192 | CA126201 | U.S. | 2008 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 48 |
| 2 | D4T+DDI | 17 |
| 3 | AZT | 39 |
| 4 | 3TC+AZT+IDV | 35 |
| 5 | D4T+DDI+NVP | 26 |
| 6 | D4T+DDI+NFV | 35 |
| 7 | 3TC+RTV+SQV | 57 |
| 8 | 3TC+ABC+EFV+RTV+SQV | 174 |
| 9 | 3TC+ABC+APV+DDI+LPV+TDF | 122 |
| 10 | 3TC+ABC+DDI+FPV+LPV+TDF | 182 |
| 11 | 3TC+ABC+DDI+RAL+TDF | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | Y181C, G190A | V108I, V179F | K11R, V21I, V35T, K43E, E44A, R83K, K101Q, K103R, L109I, V118I, K122E, R172K, D177E, G196E, R211K, D218E, L228R, T286P, A288S, I293V, E297R |
| >CA126201| codons 1-298 PISPIETVPVRLKPGMDGPKIKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLQKRKSVTIIDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEIFI CQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPERKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKSLTEVVPLTRE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | V11I, G73S, L89V | L10I, I13IV, K14R, K20V, L63P, A71I, P79A, I93L |
| >CA126200| codons 1-99 PQITLWQRPIITVRIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKIISTVLVGATPVNVIGRNVMTQLGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| T112V, M154L, V201I |
| >CA128613| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESLNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |