<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA14192 CA126200 U.S. 2008 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC 48
2 D4T+DDI 17
3 AZT 39
4 3TC+AZT+IDV 35
5 D4T+DDI+NVP 26
6 D4T+DDI+NFV 35
7 3TC+RTV+SQV 57
8 3TC+ABC+EFV+RTV+SQV 174
9 3TC+ABC+APV+DDI+LPV+TDF 122
10 3TC+ABC+DDI+APV+LPV+TDF 182
11 3TC+ABC+DDI+RAL+TDF 35

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M V11I, G73S, L89V L10I, I13IV, K14R, K20V, L63P, A71I, P79A, I93L  
>CA126200| codons 1-99
PQITLWQRPIITVRIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKIISTVLVGATPVNVIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y K219R Y181C, G190A V108I, V179F K11R, V21I, V35T, K43E, E44A, R83K, K101Q, K103R, L109I, V118I, K122E, R172K, D177E, G196E, R211K, D218E, L228R, T286P, A288S, I293V, E297R  
>CA126201| codons 1-298
PISPIETVPVRLKPGMDGPKIKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV
FAIKKKDSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLQKRKSVTIIDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEIFI
CQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPERKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKSLTEVVPLTRE

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    T112V, M154L, V201I  
>CA128613| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESLNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

References
Author Title Citation
Rhee, SY HIV-1 protease mutations and protease inhibitor cross resistance. AAC, 2010