Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4001 | CA12599 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 95 |
| 2 | 3TC+AZT | 8 |
| 3 | 3TC+AZT+IDV | 65 |
| 4 | D4T+DDI+NFV | 99 |
| 5 | ABC+IDV+NVP+RTV | 8 |
| 6 | D4T+DDI+IDV+RTV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E | L10I, K20R, M36I, K55R, I62V, L63P, A71V |
| >CA12599| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVREYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, V75T, T215F | K219Q | Y181C | V108I | K20R, T39N, K104Q, V118I, K122P, I142V, K166R, D177E, F214L | P1H |
| >CA12259| codons 1-285 HISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTILDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |