Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4990 | CA12578 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+DDI | 13 |
| 3 | 3TC+D4T+SQV | 39 |
| 4 | 3TC+AZT+IDV | 117 |
| 5 | ABC+ADV+D4T+NVP | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, L90M | L10I, E35D, N37D, D60E, I62V, L63C, A71T, V77I, I93L, C95F |
| >CA12578| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFMKVRQYE QVCIEICGHKTIGTVLIGPTPVNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, V75I, F77L, F116Y | Y181C | S68G, K101Q, K122E, S134SR, I142V, S162C, R211K, F214L, H221Y, I293V, E297T | T131TA |
| >CA12256| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYYSVPL DEDFRKYTAFAIPRINNETPGVRYQYNVLPMGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTTEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |