Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5039 | CA12568 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 104 |
| 2 | 3TC+ AZT | 104 |
| 3 | 3TC+ AZT+ SQV+ RTV | 50 |
| 4 | EFV+ ABC+ APV | 77 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | V11VI, L33F, G73GS, L89LV | L10I, T12PS, I13V, K14KR, L19I, K20I, M36I, D60DE, I62IV, L63P, A71V |
| >CA12568| codons 1-99 PQITLWQRPIIPVRIGGQIIEALLDTGADDTVFEEINLPGRWKPKMIGGIGGFVKVRQYE QVPIEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | L100I, K103N | K20R, T39AE, E40F, K43E, V60I, K101R, V118I, K122E, I135T, G196E, E203K, Q207E, R211K | N265IS |
| >CA12313| codons 1-270 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGIRKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLIWASQI |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |