Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5038 | CA12550 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+SQV | 13 |
| 2 | APV+D4T+EFV+RTV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, L90M | L10I, E35D, N37Y, R41K, L63P, A71T, V77I, I93L |
| >CA12550| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMYLPGKWKPKMIVGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E28A, S68G, I142V, S162C, K173KR, Q174K, T200E, E203K, R211G, T215X, V245K, K259KR, A272P |
| >CA12312| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRKNPDIVI YQYVDDLYVGSDLEIGQHREKIKELRQHLLGWGFXTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQRLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |