Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4894 | CA12535 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 35 |
| 2 | D4T | 65 |
| 3 | 3TC+AZT | 13 |
| 4 | 3TC+AZT+IDV | 65 |
| 5 | DDI+NFV+NVP | 22 |
| 6 | 3TC+D4T+IDV | 61 |
| 7 | 3TC+D4T+EFV+IDV | 26 |
| 8 | 3TC+D4T+EFV+IDV+RTV | 6 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | W6WC, L10I, T12E, R41K, K55R, I62V, L63P, I72X, V77I |
| >CA12535| codons 1-99 PQITLCQRPIVEIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIRVRQYD QVPIEICGHKAXTTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184I, T215F | K219Q | Y181C, Y188L, G190A | T69N, V90I, K102E, K122E, D123Q, I135T, S162Y, D177E, I178M, R211K, D218DG, D237DE, V245K, K277R, Q278E |
| >CA12000| codons 1-280 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKEKKSVTVLDVGDAYFSVPL DEQFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEMVI CQYIDDLLVASDLEIGQHRTKIEELRQHLLKWGFFTPGQKHQKEPPFLWMGYELHPEKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELC |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |