Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1317 | CA12527 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | NA |
| 2 | 3TC+ AZT+ DDI | NA |
| 3 | None | 3 |
| 4 | D4T+ DDI+ IDV | 53 |
| 5 | 3TC+ AZT+ SQV | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | V75I, F77L, F116Y | E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288S |
| >CA12527| codons 1-291 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTKMEKEGQISRVGPENPYNNPV FAIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDTKHQKEPPFLWMGYELHPDKWT VQPITLPDKEDWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S, L90M | L10F | I15V, K20T, E35D, M36I, R41K, R57K, I62V, L63P, C67CY, A71AT, I93L |
| >CA12807| codons 1-99 PQITLWQRPFVTIKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QVPIEIYGHKTIGTVLVGPTPVNIIGRSLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |