Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4414 | CA12507 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 12 |
| 2 | AZT+ 3TC | 9 |
| 3 | DDI+ D4T+ NVP | 24 |
| 4 | D4T+ NVP | 43 |
| 5 | D4T+ EFV+ SQV | 12 |
| 6 | D4T+ EFV+ SQV | 25 |
| 7 | D4T+ 3TC+ ABC+ NFV+ APV | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N, Y181C | P225PH | T27S, K49R, V60VI, R83K, V90I, K102KR, D123E, I135LV, D177E, G196GE, R211K, A272P, K277R, I293V | K281K* |
| >CA12507| codons 1-293 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC*LLRGTKALTEVV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TA, I15LV, N37D, D60E, L63S | G16GV |
| >CA12784| codons 10-99 LVAIKLVGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYEQISIEICGH KAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |