Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5202 | CA12504 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | 3TC+AZT+D4T | NA |
| 3 | 3TC+D4T+IDV+NFV+SQV | NA |
| 4 | ABC+D4T+DDI+EFV+APV+RTV | NA |
| 5 | Unknown | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, T215Y | K219R | Y181C, G190A | V108I | T39TA, K43EQ, K101T, K102Q, D121C, K122E, I135T, K166Q, D177E, I178L, H221Y, V245E, A272P, K277R |
| >CA12504| codons 1-290 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLTQKKSVTILDVGDAYFSVPL CEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKQNPELVI CQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IM, I84V, L90M | L33LF, G73ST | L10I, R57K, L63P, K70R, A71V, V77I |
| >CA12781| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFMKVKQYD QIPIEICGHRVISTVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |