Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DR92 | 03ZA.DR92 | South Africa | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+D4T+IDV | NA |
| 2 | D4T+EFV+LPV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R | T215C, K219Q | V106M, Y188YC, G190GA | P4S, V35T, T39E, V60I, K122E, I135V, S163C, K166R, K173V, D177E, Q197I, T200A, I202V, Q207E, R211K, L228H, V245Q, A272P, K277R, E291D, V292I, I293V, K311KR, V317A | I244IR, I274IS |
| >03ZA.DR92| codons 1-333 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSCMTRILEPFRVQNPEIVI YQYMDDLCVASDLEIGIHRAKVEELREHLLKWGFCTPDQKHQKEPPFHWMGYELHPDKWT VQPRQLPEKDSWTVNDIQKLVGKLNWASQIYPGSKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILREPVHGAYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, L90M | T12S, I13IV, I15V, L19IT, K20R, M36I, L38LV, R41K, D60E, Q61E, I62IV, L63P, H69K, L89M, I93L |
| >03ZA.DR92| codons 1-99 PQITLWQRPLVSVKVGGQTREALLDTGADDTVLEEINVPGKWKPKMIGGIGGFIKVRQYE EVPIEICGKKAIGTVLVGPTPANIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Pillay, V | HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. | ARHR, 2008 |