Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| DR23 | 02ZA.DR23 | South Africa | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+DDI+IDV+LPV+MKC442 | NA |
| 2 | 3TC+ABC+AZT | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | T215TI, K219Q | K103S | E138KQ | K20KR, V35T, E36A, T39E, V60VI, K102R, K122E, D123G, I142K, S162A, K173T, Q174K, D177E, I178M, V179VI, T200A, Q207D, R211K, F214L, V245Q, A272P, K277KR, E291D, V292I, I293V, K311R, D324E |
| >02ZA.DR23| codons 1-333 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRSKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNQTPGKRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMII YQYVDDLYVGSDLEIGQHRAKIEELRDHLLKWGLITPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, G16A, G17D, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93L |
| >02ZA.DR23| codons 1-99 PQITLWQRPLVSIKVADQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Pillay, V | HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy. | ARHR, 2008 |