Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5158 | CA12453 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 48 |
| 2 | D4T | 17 |
| 3 | AZT+D4T | 30 |
| 4 | D4T+DDI+3TC+SQV | 195 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | E28K, K32E, T39TA, K43KN, E44D, V118I, K122E, I135V, S162C, I178M, R211K, K223Q, K277R, I293V |
| >CA12453| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICAELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | F53L | L10I, I13V, K20M, R41K, L63P, I64V, A71V |
| >CA12741| codons 1-99 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPVEICGHKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |