<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5158 CA12453 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 48
2 D4T 17
3 AZT+D4T 30
4 D4T+DDI+3TC+SQV 195

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y       E28K, K32E, T39TA, K43KN, E44D, V118I, K122E, I135V, S162C, I178M, R211K, K223Q, K277R, I293V  
>CA12453| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICAELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M F53L L10I, I13V, K20M, R41K, L63P, I64V, A71V  
>CA12741| codons 1-99
PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD
QIPVEICGHKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005