<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5147 CA12440 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 87
2 DDC 114
3 AZT+ DDC+ 3TC 50
4 IDV+ AZT+ 3TC 134

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y K219R     K43S, E44D, E53D, V118I, K122E, S162Y, Q174E, Q197L, E203K, R211K, K223Q, L228R, A272P, T286A  
>CA12440| codons 1-297
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELESDGKISKIGPDNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKENPDIVI
YQYVDDLYVGSDLEIGLHRTKIKELRQHLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A L24I L19V, I64V, I72M  
>CA12725| codons 1-99
PQITLWQRPLVTIKIGGQVKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD
QILVEICGHKAMGTVLVGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005