Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA1549 | CA12427 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT+DDI | 187 |
2 | 3TC+AZT | 67 |
3 | 3TC+D4T+IDV | 39 |
4 | DDC+DLV+NFV+SQV | 22 |
5 | 3TC+D4T+NFV+SQV | 63 |
6 | APV+D4T+EFV | 35 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, T69D, L210W, T215Y | K219R | K103N | K43E, E44A, A98S, V111I, V118I, I135T, I142V, E203K, H208Y, R211K, F214L, K223Q, L228R, I257L, A272P, I274IV, K277R, T286A, I293V | I270IL |
>CA12427| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELRQYLWKWGLYTPDRKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQLYPGVKVRQLCKLLRGAKALTEVVPLTEEAE LE |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46L, I54V, V82A | L24I, L33I, K43T, G73S | L10I, I15V, K20R, M36I, Q61N, L63P, A71V |
>CA12713| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVIEEINLPGRWTPKLIGGIGGFVKVRQYD NIPIEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF |
References
Author | Title | Citation |
Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |