Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5111 | CA12400 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 100 |
| 2 | 3TC+AZT | 13 |
| 3 | 3TC+AZT+IDV | 78 |
| 4 | D4T+DDI+NVP | 48 |
| 5 | ABC+RTV+SQV | 55 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219Q | Y181C | V179D | T39A, V60I, A158S, S162C, G196E, Q207A, R211K, D218E, L228H, V245K, I293V, E297EA |
| >CA12400| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQCSMTKILEPFRKQNPDIDI CQYMDDLYVGSDLEIEQHRTKIEELRAHLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V | K43T | L10I, E35D, M36I, N37S, R41K, L63P, I64V, A71T, T74S, I93L |
| >CA12680| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDISLPGKWTPKMIGGIGGFVKVRQYD QIPVEICGHKTIGSVLVGPTPTNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |