Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5076 | CA12358 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 52 |
| 2 | AZT+DDC | 60 |
| 3 | 3TC+AZT | 78 |
| 4 | D4T+DDI+NVP | 106 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151LM, T215F | F116Y, K219Q | K103NS, Y181C | K20R, T27S, V35I, V60I, R83K, I135T, I167IV, Q197E, R211K, D218E, K259KE, A272P | K277KE |
| >CA12358| codons 1-287 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPLGWKGSPAIFQSSMTKVLEPFRKQNPDIVI CQYMDDLYVGSDLEIGEHRTKIEELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQELVGKLNWASQIYPGIKVEQLCKLLRGTK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L5X, L10X, L19I, E35D, N37S, L63P, I72V, V77I, I93L |
| >CA12641| codons 1-99 PQITXWQRPXVTIKIGGQIKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |