Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1257 | CA123363 | U.S. | 2008 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | AZT+DDC | 8 |
| 3 | 3TC+AZT | 44 |
| 4 | 3TC+AZT+SQV | 35 |
| 5 | 3TC+D4T+IDV | 37 |
| 6 | 3TC+D4T+IDV+NVP | 189 |
| 7 | 3TC+D4T+LPV+NVP | 43 |
| 8 | 3TC+D4T+LPV+NVP+TDF | 239 |
| 9 | Unknown | 105 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, G73S | T12P, I13V, I15V, L19P, K20I, E35G, M36I, L63P, A71V, I72L, I93L |
| >CA123363| codons 1-99 PQITLWQRPFIPVKVGGQPIEALLDTGADDTVLEGINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219DN | Y181C, G190A | K101H | T39TA, K43Q, E44D, K49R, V60I, V106VI, V118I, K122E, D123E, I135T, T200A, D218E, D250E, L283I, R284K, I293V, P294Q, E297A |
| >CA123364| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISRIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKIEELRQHLWRWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVQLTAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |