Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5056 | CA12336 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 117 |
| 2 | 3TC+AZT | 74 |
| 3 | D4T+DDI+NFV | 78 |
| 4 | EFV+RTV+SQV | 27 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W | D67G, T215AD | K103N | T39A, E44D, S68G, K102R, I142V, V179I, G196E, R211T, D237E |
| >CA12336| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKGGDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLWTWGFATPDKKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S, L90M | L10V, R41K, Q61H, L63P, K70R, V77I |
| >CA12620| codons 10-99 VVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYDHIPIEICGH RAIGTVLIGPTPVNIIGRSLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |