<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4001 CA12259 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 95
2 3TC+AZT 8
3 3TC+AZT+IDV 65
4 D4T+DDI+NFV 99
5 ABC+IDV+NVP+RTV 8
6 D4T+DDI+IDV+RTV 9

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F V75T, K219Q Y181C V108I K20R, T39N, K104Q, V118I, K122P, I142V, K166R, D177E, F214L P1H
>CA12259| codons 1-285
HISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKQSVTILDVGDAYFSIPL
DPDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M Q58E L10I, K20R, M36I, K55R, I62V, L63P, A71V  
>CA12599| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVREYD
QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005