<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-9447 P9447-611 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 54
2 DDC 49
3 D4T 10
4 NRTI 42
5 3TC+ AZT 22
6 3TC+ DDC+ IDV 18
7 3TC+ NVP+ SQV+ AZT 27
8 3TC+ NVP+ SQV+ AZT+ NFV 9

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M F53FL, G73S M46X, L63P, A71V, V77I, I93L  
>P9447-611| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKXIGGIGGLIKVRQYD
QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       T39A, T69A, K103R, S162C, I167X, D186X, T200A, Q207E  
>P9447-611| codons 26-240
LTEEKIKALVEICAELEKEGKISKIGPENPYNTPVFAIKKKDSAKWRKLVDFRELNKRTQ
DFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQ
YNVLPQGWKGSPAIFQCSMTKMLEPFRKQNPDIVIYQYVDELYVGSDLEIGQHRAKIEEL
REHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005