Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-9447 | P9447-611 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 54 |
| 2 | DDC | 49 |
| 3 | D4T | 10 |
| 4 | NRTI | 42 |
| 5 | 3TC+ AZT | 22 |
| 6 | 3TC+ DDC+ IDV | 18 |
| 7 | 3TC+ NVP+ SQV+ AZT | 27 |
| 8 | 3TC+ NVP+ SQV+ AZT+ NFV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | F53FL, G73S | M46X, L63P, A71V, V77I, I93L |
| >P9447-611| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKXIGGIGGLIKVRQYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | T39A, T69A, K103R, S162C, I167X, D186X, T200A, Q207E |
| >P9447-611| codons 26-240 LTEEKIKALVEICAELEKEGKISKIGPENPYNTPVFAIKKKDSAKWRKLVDFRELNKRTQ DFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQ YNVLPQGWKGSPAIFQCSMTKMLEPFRKQNPDIVIYQYVDELYVGSDLEIGQHRAKIEEL REHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |