Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA639 | CA1218 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 56 |
2 | AZT+ DDC | 13 |
3 | AZT+ DDI | 34 |
4 | 3TC+ AZT | 21 |
5 | 3TC+ AZT+ D4T | 13 |
6 | 3TC+ AZT+ SQV | 17 |
7 | 3TC+ D4T+ IDV | 69 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
G48V, I54T, V82A | L10I, E35D, M36I, L63P, A71V |
>CA1218| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIVGIGGFTKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, M184V, L210W, T215Y | D121Y, K122E, I135V, S162C, T200A, R211K |
>CA1219| codons 31-240 IKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEV QLGIPHPAGLKKKKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSVNNETPGIRYQYNVLP QGWKGSPAIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLW KWGFYTPDKKHQKEPPFLWMGYELHPDKWT |
References
Author | Title | Citation |
Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |