Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4914 | CA12111 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+ DDI+ D4T | 20 |
| 2 | SQV+ AZT+ RTV | 4 |
| 3 | 3TC+ AZT+ NFV+ NVP | 9 |
| 4 | 3TC+ NFV+ NVP | 16 |
| 5 | 3TC+ NVP | 26 |
| 6 | EFV | 8 |
| 7 | EFV+ ABC | 9 |
| 8 | IDV+ ABC+ 3TC+ RTV | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | L10I, L24F, N37D, L63P, A71V, V77I, I93L |
| >CA12111| codons 1-99 PQITLWQRPIVTIKIGGQLKEALFDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, V75M, M184V, L210W | T215C | Y181YC, Y188L | K122E, R172RK, I178IM, Q207E, R211K, H221HY, A272P, K277R, T286A, A288AG, V292I | K287KT |
| >CA12022| codons 1-294 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIIP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |