Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4908 | CA12105 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 109 |
| 2 | AZT+DDI | 61 |
| 3 | AZT+DDI+SQV | 61 |
| 4 | 3TC+AZT+NVP | 17 |
| 5 | 3TC+AZT+NFV | 26 |
| 6 | EFV+RTV+SQV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | Q58E, G73S | L10I, I15V, K20I, L63P |
| >CA12105| codons 1-99 PQITLWQRPIVTIKVGGQLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPIEICGHKAISTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V106A, G190A | V179D, F227L | V35I, K43Q, V118I, D123E, K166R, D177E, G196E, R211K, T286A, I293V, E297K |
| >CA12016| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIDI YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |