<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1165 CA12092 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 52
2 DDC 52
3 D4T 52
4 3TC+AZT+SQV 48
5 3TC+AZT+NFV 13
6 3TC+AZT+IDV+NVP 20
7 3TC+AZT+DLV+RTV+SQV 13
8 3TC+AZT 27
9 3TC+AZT+EFV+SQV 4
10 3TC+AZT+SQV 18
11 3TC+AZT 4
12 None 6
13 3TC+AZT+IDV+NVP+RTV 35

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82T   L10I, T12P, K14R, E35D, N37D, L63P, C67D, A71T  
>CA12092| codons 1-99
PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIVGIGGFVKVRQYD
QIPIEIDGHKTIGTVLVGPTPTNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, T215Y K219R K103N A98G, V108VI K20R, V60I, V118I, K122E, I135M, G196E, F214L, L228H, K259KR, Q278QH, A288S, I293V, E297R, A304G  
>CA12002| codons 1-304
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLYTPDRKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQRLVGKLNWASQIYAGIKVKHLCKLLRGTKSLTEVVPLTREAE
LELG

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005