Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1165 | CA12092 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDC | 52 |
| 3 | D4T | 52 |
| 4 | 3TC+AZT+SQV | 48 |
| 5 | 3TC+AZT+NFV | 13 |
| 6 | 3TC+AZT+IDV+NVP | 20 |
| 7 | 3TC+AZT+DLV+RTV+SQV | 13 |
| 8 | 3TC+AZT | 27 |
| 9 | 3TC+AZT+EFV+SQV | 4 |
| 10 | 3TC+AZT+SQV | 18 |
| 11 | 3TC+AZT | 4 |
| 12 | None | 6 |
| 13 | 3TC+AZT+IDV+NVP+RTV | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82T | L10I, T12P, K14R, E35D, N37D, L63P, C67D, A71T |
| >CA12092| codons 1-99 PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIVGIGGFVKVRQYD QIPIEIDGHKTIGTVLVGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, T215Y | K219R | K103N | A98G, V108VI | K20R, V60I, V118I, K122E, I135M, G196E, F214L, L228H, K259KR, Q278QH, A288S, I293V, E297R, A304G |
| >CA12002| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLYTPDRKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQRLVGKLNWASQIYAGIKVKHLCKLLRGTKSLTEVVPLTREAE LELG |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |