Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1288 | CA12053 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 4 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+AZT+IDV | 43 |
| 4 | AZT+DDI+IDV+NVP | 17 |
| 5 | 3TC+D4T+RTV+SQV | 82 |
| 6 | 3TC+D4T+EFV+SQV | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V | L24I, G73GC | L10I, E34Q, N37A, R41K, I62V, L63A, A71V, V77I, I93L |
| >CA12053| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLQEMALPGKWKPKMIGGIGGFVKVRQYD QVAIEICGHKVICTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | K103N | A98AG, P225PH | L100LV, K122E, D123N, I135T, I142IL, Q207E, R211K, F214L, V245T | K259K* |
| >CA11962| codons 1-274 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGVKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGLRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGLTTPDQKHQKEHPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQ*LVGKLNWASQIYAGI |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |