Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1419 | CA12029 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 43 |
| 2 | DDI | 12 |
| 3 | DDI+ AZT | 35 |
| 4 | AZT+ 3TC | 56 |
| 5 | SQV+ AZT+ 3TC | 17 |
| 6 | IDV+ AZT+ 3TC | 39 |
| 7 | NFV+ D4T | 47 |
| 8 | NVP+ DDC+ D4T | 20 |
| 9 | SQV+ RTV+ DDI | 24 |
| 10 | EFV+ ABC | 15 |
| 11 | EFV+ ABC+ NFV | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | D60DE, I62V, L63P, A71V, V77I, I93L |
| >CA12029| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYE QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219E | K103N, Y181I, G190A | K122KE, D123E, G196E, R211K, V245T, E248D, T286A, E297K, M357T, A376T, T377M, S379C, T386A, K390R, Q394L, A400T, V435I, V458I, R461K, S468T, H483Y, K530R, K558R |
| >CA11940| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI IQYMDDLYVASDLEIEQHRTKIEELRQHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPITLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKITMECIVIWGKAPKFRLPILKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYITDKGRQKVVTLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSAGIRRVL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |