Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA631 | CA1202 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDC | 78 |
| 3 | D4T | 17 |
| 4 | DDI | 13 |
| 5 | 3TC+AZT+SQV | 30 |
| 6 | 3TC+AZT+IDV | 21 |
| 7 | 3TC+D4T+SQV+RTV | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | F53FL, G73S | L10I, K20R, E35D, M36I, N37D, Q61E, I62V, L63P, A71T, I72K, V77I, I93L |
| >CA1202| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGLIKVRQYD EVPIEICGHKTKSTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | E6D, V35X, T39A, E44D, V118I, K173T, E203K, Q207D, H208Y, R211K |
| >CA1203| codons 1-233 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALXEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELRDYLWKWGFYTPDNKHQKEPPFLWMGYE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |