Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4850 | CA11941 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 48 |
| 2 | DDI | 57 |
| 3 | 3TC+AZT+D4T | 44 |
| 4 | 3TC+AZT+NVP+RTV | 26 |
| 5 | 3TC+AZT+NFV | 44 |
| 6 | D4T+DDI+NVP | 44 |
| 7 | 3TC+AZT+DDI+EFV+IDV+RTV | 39 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L210W, T215F | K219Q | L100LI, Y188L | M16V, V35L, T39A, K43KN, K122E, T139TA, G196E, Q207E, L228H, V245E, A272P, T286A, E297R |
| >CA11941| codons 1-302 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALLEICAELENEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIEQHRTKIEELREHLWRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10I, I62V, L63P, A71V, I72V, V77I, I93L |
| >CA12030| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVVGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |