Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA627 | CA1194 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 217 |
| 2 | DDC | 44 |
| 3 | AZT | 39 |
| 4 | D4T | 13 |
| 5 | 3TC+AZT | 17 |
| 6 | 3TC+AZT+SQV | 13 |
| 7 | 3TC+AZT+IDV | 17 |
| 8 | 3TC+D4T | 13 |
| 9 | 3TC+D4T+NFV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I15V, E35D, M36I, L63P |
| >CA1194| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V, T215Y | E6D, I31IL, I47IF, R83K, K102KR, K122E, I135IL, S162C, Q207E | R72RG |
| >CA38024| codons 1-249 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKLKALVEICTELEKEGKFSKIGPENPYNTPV FAIKKKDSTKWGKLVDFRELNKKTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEK |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |