Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU017 | ASRU017 | U.K. | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+SQV | 35 |
| 2 | 3TC+AZT+IDV | 52 |
| 3 | D4T+DDI+RTV+SQV | 4 |
| 4 | D4T+DDI+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_S, T215Y | Y181C, G190A | V35T, K49R, V60I, D121C, K122E, I132X, I135T, D177E, I178M, L205X, Q207E, R211K |
| >ASRU017| codons 1-235 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPI FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL CEDFRKYTAFTXPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYMDDLYVASDLEIGQHRTKIEEXREHLLKWGFYTPDKKHQKEPPFLWMGYELH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, T12S, I15V, K20T, E35G, M36I, R41K, I64V, A71T, I85V, I93L |
| >ASRU017| codons 1-99 PQITLWQRPIVSIKVGGQLTEALLDTGADDTVLEGINLPGKWKPKMIGGIGGFIKVRQYD QILVEICGHKTIGTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |