Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU015 | ASRU015 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 43 |
| 2 | AZT+ DDC | 43 |
| 3 | 3TC+ D4T+ RTV | 43 |
| 4 | 3TC+ ADV+ D4T+ RTV | 13 |
| 5 | ADV+ DDI+ NFV | 4 |
| 6 | ADV+ AZT+ DDI+ NFV+ SQV | 4 |
| 7 | ADV+ DDI+ NFV+ SQV | 12 |
| 8 | ADV+ DDI+ NFV+ NVP+ SQV | 17 |
| 9 | DDI+ NFV+ NVP+ SQV | 41 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y181C, G190A | K20R, E44D, D86E, K101Q, V118I, K122E, S162C, I178L, R211K, E224X |
| >ASRU015| codons 1-233 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQEFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKDPPFLWMGYE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | Q58E | L10I, L19I, K20R, E35D, M36I, L63P, A71V, V77I, I93L |
| >ASRU015| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVREYD QIPIEICGHKVIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |