Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU021 | ASRU021 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 30 |
| 2 | 3TC+ AZT | 39 |
| 3 | 3TC+ D4T+ SQV | 78 |
| 4 | D4T+ NFV+ NVP | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | E35D, M36I, N37D, R57K, L63P, A71T |
| >ASRU021| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDIDLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKTIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215Y | K103N, Y181C | E6D, K20R, K43N, E44D, I50V, E169D, L210S, D218E |
| >ASRU021| codons 1-235 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKVGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLSRWGFYTPEKKHQKEPPFLWMGYELH |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |