Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU019 | ASRU019 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 8 |
| 2 | AZT+ DDC | 30 |
| 3 | AZT | 17 |
| 4 | AZT+ RTV | 4 |
| 5 | AZT | 8 |
| 6 | AZT+ SQV | 12 |
| 7 | 3TC+ D4T+ SQV | 34 |
| 8 | DDI+ D4T+ IDV+ NVP | 43 |
| 9 | EFV+ ABC+ IDV+ NFV | 4 |
| 10 | EFV+ IDV+ NFV | 2 |
| 11 | EFV+ IDV+ NFV+ DDI | 2 |
| 12 | 3TC+ DDI+ EFV+ IDV+ NFV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, E35G, M36I, Q61E, L63P, A71V, I72V, I93L | V11G |
| >ASRU019| codons 1-99 PQITLWQRPIGTIKIGGQLKEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFIKVRQYD EIPIEICGHKVVSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219N | Y181C, G190A | V108I | P4X, K20R, E44D, A98S, K101Q, K103R, V118I, K122E, Q207E, R211K | Q145D |
| >ASRU019| codons 1-233 PISXIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKRKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYDYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYIDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |