Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU018 | ASRU018 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 313 |
| 2 | AZT+ DDI | 91 |
| 3 | AZT+ DDI+ SQV | 34 |
| 4 | 3TC+ D4T+ RTV | 4 |
| 5 | 3TC+ D4T+ IDV | 13 |
| 6 | 3TC+ D4T+ NFV+ NVP | 21 |
| 7 | ABC+ APV+ AZT+ DDC+ EFV | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, L63P, A71V, V77I |
| >ASRU018| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFTKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74V, L210LW, T215Y | K219KQ | K101E, Y181C | G190R | T39A, E44D, V118I, K122E, V189VI, E203X, R211K |
| >ASRU018| codons 1-236 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYIRSDLEIGQHRTKIXELRQHLWKWGFYTPDQKHQKEPPFLWMGYELHP |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |