Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ASRU016 | ASRU016 | U.K. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | 3TC+ AZT | 39 |
| 3 | D4T+ DDI | 3 |
| 4 | IDV | 4 |
| 5 | IDV+ NVP | 6 |
| 6 | IDV+ NVP+ SQV | 53 |
| 7 | ABC+ DLV+ NFV | 1 |
| 8 | DLV+ NFV | 1 |
| 9 | NFV | 1 |
| 10 | DLV+ NFV | 1 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y181C | K101N | K20R, Y56X, S162Y, E169D, T200A, H221L |
| >ASRU016| codons 1-235 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENP*NTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKLQKEPPFLWMGYELH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | I15V, K20V, E35D, N37S, R41K, I62V, L63P, A71X |
| >ASRU016| codons 1-99 PQITLWQRPLVTIKVGGQLVEALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKXISTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |