<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ASRU016 ASRU016 U.K. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT NA
2 3TC+ AZT 39
3 D4T+ DDI 3
4 IDV 4
5 IDV+ NVP 6
6 IDV+ NVP+ SQV 53
7 ABC+ DLV+ NFV 1
8 DLV+ NFV 1
9 NFV 1
10 DLV+ NFV 1

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M G73S I15V, K20V, E35D, N37S, R41K, I62V, L63P, A71X  
>ASRU016| codons 1-99
PQITLWQRPLVTIKVGGQLVEALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKXISTVLVGPTPVNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y181C K101N K20R, Y56X, S162Y, E169D, T200A, H221L  
>ASRU016| codons 1-235
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENP*NTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKLQKEPPFLWMGYELH

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005