Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4816 | CA11871 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 24 |
| 2 | 3TC+D4T+NFV | 21 |
| 3 | 3TC+DDI+NVP | 17 |
| 4 | DDI+NVP+RTV+SQV | 17 |
| 5 | ABC+EFV+NFV | 27 |
| 6 | 3TC+ABC+AZT+IDV+RTV | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | N88D | L10I, I13V, K14R, I15V, N37D, K45R, I62V, L63P, V77I, I93L |
| >CA11871| codons 1-99 PQITLWQRPIVTVRVGGQLKEALLDTGADNTVLEEMDLPGRWKPRMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V | Y181C, G190GS | V35L, V106I, K122E, K173T, Q174R, T200TA, Q207E, R211K, F214L, H221Y, D237DE, A272P, K277R, I293V, P294AS |
| >CA11720| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRNPDIVI CQYMDDLYVSSDLEIGQHRAKIEELREHLLKWGLTTPDKKYQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVALTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |